Stand-in goalkeeper David Ospina had a night to forget as Arsenal slumped to a 3-2 home defeat against Olympiakos on Wednesday to leave their Champions League hopes in jeopardy.
Late goals from Sergi Roberto and Luis Suarez saved Barcelona's blushes and earned them a valuable win over visitors Bayer Leverkusen in Champions League Group E.
Robert Lewandowski's incredible goal scoring form continued as the striker's hat trick helped Bayern Munich thrash Dinamo Zagreb 5-0.
Belarusian champions BATE Borisov shocked Italian side Roma with a 3-2 win at the Borisov-Arena in Champions League Group E.
Valencia got their Champions League campaign up and running with a 1-0 victory at Lyon in Group H.
Oleg Shatov's second-half goal earned Zenit St Petersburg a 2-1 Champions League victory over Gent at the Petrovsky Stadium on Tuesday night to strengthen their position at the top of Group H.
Goals from Andriy Yarmolenko and Aluisio Junior Moraes gave Dynamo Kiev a 2-0 Champions League victory over Maccabi Tel-Aviv in Group G.
Champions League holders Barcelona saw their perfect start to the season ended after they were held to a 1-1 draw by Roma at the Stadio Olimpico in Wednesday's Group E opener.
Diego Costa scored his first Champions League goal for Chelsea as the beleaguered Premier League champions claimed a much-needed fillip by thrashing Maccabi Tel Aviv at Stamford Bridge.
Arsenal had striker Olivier Giroud sent off as they slumped to a disappointing 2-1 defeat in their Champions League Group F opener at Dinamo Zagreb.
Thomas Muller's scoring streak continued as he netted a brace to steer Bayern Munich to a 3-0 win at Olympiakos in their Champions League Group F opener.
Hakan Calhanoglu scored a brace either side of Javier Hernandez's first goal for Bayer Leverkusen as the German side made a winning start in Champions League Group E by seeing off BATE Borisov 4-1 at home.
Zenit St Petersburg got their Champions League campaign off to a winning start as they recorded a 3-2 victory at Valencia in Wednesday's Group H opener.
Gent fought back to clinch a point in a heroic display after having two men sent off in their first ever Champions League group match which ended 1-1 against Lyon.
Luke Shaw suffered a horrific suspected broken leg as Manchester United's return to the Champions League ended in a disappointing 2-1 defeat to PSV Eindhoven.
Manchester City suffered familiar European wobbles as they surrendered a lead to lose their Champions League Group D opener 2-1 to Juventus.
Cristiano Ronaldo hit a second-half hat trick as Real Madrid opened their Champions League campaign with a 4-0 victory over 10-man Shakhtar Donetsk in Tuesday's Group A showdown at the Santiago Bernabeu.
Angel Di Maria opened his account for Paris Saint-Germain as they began their Champions League Group A campaign with a 2-0 victory over Malmo.
Sevilla scored two second-half penalties and missed another as they defeated Borussia Monchengladbach 3-0 in their opening Champions League group-stage clash.
Antoine Griezmann struck twice in the first half as Atletico Madrid made an ideal start to their Champions League campaign with a 2-0 victory at Galatasaray.
Benfica opened their Champions League campaign with a 2-0 victory over group stage new boys Astana in Lisbon.
Julian Draxler's first-half goal made the difference for Wolfsburg in their Champions League clash against CSKA Moscow at the Volkswagen Arena.
Manchester City have been handed a tough Champions League Group stage draw against Juventus, Sevilla and Borussia Monchengladbach.
Lionel Messi was named the UEFA Best Player in Europe for the 2014-15 season for helping Barcelona to a Treble of trophies.
Manchester United advanced to the Champions League group stages as Wayne Rooney netted a hat trick to help beat Club Brugge 4-0 in Belgium to advance 7-1 on aggregate.
Valencia lost 2-1 at Monaco but advanced from their Champions League playoff on an aggregate 4-3 score Tuesday, giving Spain a record five teams in the group stage.
Celtic's Champions League hopes ended amid some controversy as a 2-0 defeat by Malmo at the Swedbank Stadion put the Swedish side through to the group stages on a 4-3 aggregate victory.
Ukraine's Shakhtar Donetsk overcame a rocky start to qualify for the Champions League group stage on Tuesday, drawing 2-2 with Austrian side Rapid Vienna for a 3-2 aggregate win.
Leigh Griffiths scored twice as Celtic defeated FC Malmo 3-2 in their UEFA Champions League playoff first leg at Celtic Park on Wednesday.
Memphis Depay helped spare Manchester United's blushes as his first goals for the club inspired them to come from behind to defeat Club Brugge 3-1 in their Champions League playoff first leg.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.