Real Madrid beat Paris Saint-Germain 1-0 in the teams' Group A Champions League match Tuesday to secure a place in the Champions League knockout round for the 19th straight season.
Manchester City produced one of their greatest European performances to secure a place in the Champions League last 16 with a brilliant 3-1 win at Sevilla.
Stephan Lichtsteiner earned Juventus a 1-1 draw at Borussia Monchengladbach just a month after undergoing heart surgery.
Wayne Rooney ended Manchester United's 404-minute goal drought by scoring the winner against CSKA Moscow on a night of high emotion at Old Trafford.
PSV Eindhoven hauled themselves back into contention in Group B with a 2-0 win over Wolfsburg.
Shakhtar Donetsk kept their faint hopes of qualifying for the knockout stages alive after securing their first Champions League victory of the season in style with a 4-0 win at the Donbass Arena against Group A rivals Malmo.
Astana secured their second point but remain with out a win in the Champions League group stages following a goalless draw against Atletico Madrid in Kazakhstan.
Real Madrid and Paris St. Germain fought to a goalless draw in Paris to remain joint-leaders atop the Champions League Group A standings on Wednesday.
Kevin De Bruyne struck an injury-time winner as Manchester City came from behind to claim a dramatic 2-1 win over Sevilla in the Champions League.
Borussia Monchengladbach brought an end to Juventus' perfect start in the Champions League on Wednesday when they held the Serie A giants to a goalless draw in Turin.
Anthony Martial scored a delightful diving header to rescue Manchester United from a damaging defeat at CSKA Moscow.
Wolfsburg defeated PSV Eindhoven 2-0 at home in the Champions League to go top of Group B.
Atletico Madrid brushed aside Astana 4-0 on Wednesday evening to return to winning ways at the Vicente Calderon stadium in the Champions League.
Malmo remain in contention to reach the Champions League's last 16 after a 1-0 group A victory over Shakhtar Donetsk that took the Ukrainians to the brink of elimination.
Galatasaray defeated Benfica 2-1 to claim their first win in 10 fixtures in Europe and revive their hopes of advancing from Group C into the Champions League's final 16.
Olivier Giroud came off the bench to help give Arsenal a 2-0 win over Bayern Munich and keep alive their Champions League hopes.
Barcelona strengthened their position at the top of Champions League Group E as a brace from substitute Ivan Rakitic steered them to a comfortable 2-0 win at BATE Borisov.
Eden Hazard and Willian hit the woodwork as Chelsea were held to a goalless draw at Dynamo Kiev.
Bayer Leverkusen and Roma battled out a 4-4 draw in a thrilling Champions League Group E clash in Germany that saw both sides produce remarkable comebacks.
Zenit St Petersburg are on the brink of qualifying for the knockout stages of the Champions League after defeating Lyon 3-1 in Russia.
Vincent Aboubakar netted his seventh goal of the season as Porto beat Maccabi Tel-Aviv 2-0 to climb to the top of Champions League Group G.
Ideye Brown struck the decisive goal for Olympiakos at the Maksimir Stadium to send Dinamo Zagreb spinning to a second Group F Champions League defeat.
Stefan Mitrovic's own goal allowed Valencia to take a big step towards qualification from Champions League Group H as Gent were beaten 2-1 at the Mestalla.
Juan Mata was the star of the show as Manchester United got off the mark in the Champions League with a narrow 2-1 win over Wolfsburg.
Cristiano Ronaldo's double took him past 500 career goals and handed Real Madrid a narrow 2-0 Champions League victory over 10-man Malmo.
Sergio Aguero struck a last-gasp penalty winner as Manchester City came from behind to ignite their Champions League campaign with a 2-1 win at Borussia Monchengladbach.
Juventus may be struggling in Serie A but it is a different story in the Champions League with the Italian giants clinching the second win in as many games on Wednesday with a home triumph over Sevilla.
Zlatan Ibrahimovic was frustrated in his attempts to overhaul Paris St Germain's all-time goalscoring record as a late strike was officially recorded as an own goal.
Benfica came from a goal behind to beat Atletico Madrid 2-1 at the Vicente Calderon and go top of Group C.
Jose Mourinho's return to former club Porto ended in a 2-1 Champions League defeat as Chelsea's miserable start to the season continued.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.