Atletico Madrid clinched first place in Champions League Group C after winning their top-of-the-table encounter with Benfica 2-1 at the Estadio da Luz.
Galatasaray secured themselves a Europa League spot with a 1-1 Champions League Group C draw against Astana.
Mario Mandzukic scored the only goal as Juventus leapfrogged Manchester City in Champions League Group D with a 1-0 win in Turin.
Manchester United were held to a goalless draw by PSV Eindhoven at Old Trafford on Wednesday night, meaning their Champions League hopes will depend on their final group game away at Wolfsburg.
Zlatan Ibrahimovic marked his return to his hometown club by helping PSG to a 5-0 Champions League victory over Malmo at the Swedbank Stadion.
Under-fire Rafael Benitez survived a late scare on a night when Real Madrid won their Champions League group, conceding three late goals against Shakhtar Donetsk.
Wolfsburg are on the brink of qualifying for the Champions League knock-out stages after winning 2-0 at CSKA Moscow.
Atletico Madrid made sure of their place in the Champions League knock-out stages with a comfortable 2-0 win against Galatasaray at the Vicente Calderon Stadium.
Sevilla's hopes of reaching the Champions League knockout stages ended in Germany with a 4-2 defeat to Borussia Monchengladbach.
Raul Jimenez scored twice as Benfica fought back from two goals down to draw 2-2 with FC Astana in their Champions League Group C fixture and move to the brink of reaching the tournament's last 16.
Bayern Munich booked their place in the Champions League group stage with an emphatic 4-0 victory over Olympiakos.
Lionel Messi, Luis Suarez and Neymar tore Roma to shreds as Barcelona heralded their Champions League glory march with a 6-1 thumping at the Camp Nou.
Arsenal kept their Champions League hopes alive with a routine victory over Dinamo Zagreb.
Chelsea's Champions League fate will go to the final group game after an unconvincing 4-0 win over 10-man Maccabi Tel Aviv earned successive victories for the first time in two months.
Lyon are out of the Champions League after they lost their crunch Group H clash with Gent 2-1 as the Stade de Gerland hosted its final European encounter.
Porto crashed to their first defeat of the season as Group G rivals Dynamo Kiev kept their Champions League hopes alive with goals from Andriy Yarmolenko and Derlis Gonzalez at the Estadio do Dragao.
Zenit St Petersburg maintained their 100 percent record in Group H of the Champions League and guaranteed themselves top spot with a 2-0 win against Valencia.
Admir Mehmedi struck a second-half equaliser against Champions League Group E rivals BATE Borisov in Belarus to keep Bayer Leverkusen's hopes of securing a place in the knockout stages alive.
Arsenal's Champions League hopes are hanging by a thread after they were blown away by Bayern Munich on Wednesday night.
Jose Mourinho was granted a reprieve as Willian's free-kick earned a 2-1 Champions League Group G victory over Dynamo Kiev at Stamford Bridge.
Miralem Pjanic's late penalty allowed Roma to edge a resilient Bayer Leverkusen 3-2 on Wednesday and keep their hopes of qualifying for the knockout stages of the Champions League alive.
Neymar struck twice as Barcelona moved ever closer towards a place in the knockout stages of the Champions League with a 3-0 win over Group E rivals BATE Borisov.
Two second-half strikes from substitute Felipe Pardo inspired Olympiakos to a 2-1 victory over 10-man Dinamo Zagreb, sending the hosts six points clear of third-placed Arsenal in Champions League Group F.
Porto moved closer to booking their place in the last 16 of the UEFA Champions League with a 3-1 win over Maccabi Tel Aviv in Israel.
Artem Dzyuba scored twice as Zenit St. Petersburg sealed their place in the Champions League knockout stages with a 2-0 win over Lyon in France.
Sven Kums' second-half penalty was enough for Gent to down Valencia in Belgium on Wednesday night and earn the hosts an historic first win in the Champions League.
Real Madrid beat Paris Saint-Germain 1-0 in the teams' Group A Champions League match Tuesday to secure a place in the Champions League knockout round for the 19th straight season.
Manchester City produced one of their greatest European performances to secure a place in the Champions League last 16 with a brilliant 3-1 win at Sevilla.
Stephan Lichtsteiner earned Juventus a 1-1 draw at Borussia Monchengladbach just a month after undergoing heart surgery.
Wayne Rooney ended Manchester United's 404-minute goal drought by scoring the winner against CSKA Moscow on a night of high emotion at Old Trafford.
David De Gea's exceptional display saved Manchester United's blushes as Jose Mourinho's men somehow escaped with a goalless draw from a match dominated by Sevilla.
Shakhtar Donetsk pulled off a second-half comeback to beat Roma 2-1 in their Champions League round-of-16 first leg in Ukraine on Wednesday night.
Bayern Munich look assured of a Champions League quarterfinal spot for a seventh straight season after thrashing 10-man Besiktas 5-0 in Germany.
Lionel Messi broke his goal duck against Chelsea to deny Antonio Conte's side a crucial lead over Barcelona in their Champions League showdown.
Sadio Mane scored a hat trick and Mohamed Salah continued his phenomenal run with a 30th goal of the season as Liverpool won 5-0 at Porto to virtually assure themselves a Champions League quarterfinal place.
Cristiano Ronaldo scored twice and Marcelo got another as Real Madrid came from a goal down to take a 3-1 lead over Paris Saint-Germain in the first leg of their Champions League clash at the Bernabeu.
Ilkay Gundogan scored twice as Manchester City put one foot in the Champions League quarterfinals with an emphatic 4-0 win over Basel.
Christian Eriksen completed a remarkable Tottenham comeback as they rallied from two down to draw with Juventus in the Champions League last 16.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.