Manchester City lost defenders Vincent Kompany and Nicolas Otamendi to injury as they limped into the Champions League quarterfinals after a dull goalless draw against Dynamo Kiev.
Zlatan Ibrahimovic sent Chelsea of the Champions League as Paris Saint-Germain claimed a 2-1 round-of-16 second-leg win at Stamford Bridge.
Late goals from Nicolas Gaitan and Talisca sent Benfica into the Champions League quarterfinals following a 3-1 aggregate victory over Zenit St Petersburg.
Real Madrid made Roma pay for wasted opportunities as they secured a place in the quarter-finals of the Champions League for the sixth season in a row with a 2-0 win at the Bernabeu.
Wolfsburg booked their expected place in the quarter-finals of the Champions League for the first time in their history as Andre Schurrle's late goal earned them an unconvincing 1-0 home win over Gent.
Manchester City produced one of their best performances of the season to seize the advantage in their Champions League last-16 tie with a superb 3-1 win at Dynamo Kiev.
PSV Eindhoven survived the dismissal of Gaston Pereiro to hold Atletico Madrid to a goalless Champions League draw at the Philips Stadion.
Barcelona took the advantage over Arsenal in their round of 16 clash at the Emirates on Tuesday night as they won 2-0 thanks to two goals from Lionel Messi.
Juventus came from two goals down to earn a 2-2 draw in the first leg of their Champions League last-16 tie with Bayern Munich.
Real Madrid beat Roma 2-0 in their Champions League last-16 first leg at the Stadio Olimpico, with away goals from Cristiano Ronaldo and Jese giving them the upper hand.
Gent gave themselves a Champions League lifeline with two late goals in a 3-2 home defeat against Wolfsburg.
Zlatan Ibrahimovic and Edinson Cavani scored as Paris Saint-Germain took a 2-1 advantage over Chelsea in the first leg of their Champions League last-16 clash on Tuesday.
Benfica have a slender 1-0 advantage over Zenit St Petersburg after Oliveira Jonas' injury-time goal at the Estadio da Luz.
Barcelona and Argentina star Lionel Messi was awarded the 2015 Ballon d'Or at Monday's gala event in Zurich.
With four players each from Barcelona and Real Madrid, the Spanish giants combined to put eight players on the 2015 FIFPro World XI.
The highlight of the Champions League last-16 draw sees Arsenal take on Barcelona and Juventus take on Bayern Munich.
Jose Mourinho received a slice of luck and another reprieve as Chelsea advanced to the knockout stages of the Champions League as Group G winners with a 2-0 victory over his former club Porto.
Olivier Giroud inspired Arsenal to complete a Champions League group stage comeback as his hat trick at Olympiakos sealed their place in the last 16.
Bayer Leverkusen could not find a winner against Barcelona as their final Champions League Group E match ended 1-1, which saw the German side fail to qualify for the last 16 and drop into the Europa League.
Robert Lewandowski notched a quickfire brace as Bayern Munich rounded off their Champions League Group F fixtures with a 2-0 win at Dinamo Zagreb.
Gent beat Group H winners Zenit St Petersburg 2-1 at Ghelamco Arena to become the first Belgian club to get through to the knockout stages of the Champions League in 15 years.
Gary Neville watched his Valencia team slide into the Europa League after his Mestalla debut saw Lyon claim a 2-0 Champions League victory.
Denys Garmash's goal was enough to give Dynamo Kiev a 1-0 win over Maccabi Tel Aviv and send them through to the knockout stages of the Champions League.
Roma squeezed through to the Champions League last 16 after being held to a 0-0 draw at home by BATE Borisov in their final Group E game.
CSKA Moscow were unable to pull off a shock win over PSV Eindhoven, and United now face the prospect of playing Europa League football in the new year.
Sevilla will try to defend their Europa League crown after a 1-0 home win over Juventus secured them third place in Champions League Group D.
Raheem Sterling celebrated his 21st birthday with a quickfire double to send Manchester City through to the Champions League last 16 as group winners.
PSV Eindhoven secured their place in the knockout stages of the Champions League with a late 2-1 win against Group B's bottom club CSKA Moscow.
Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid hammered Malmo 8-0 to equal the highest ever victory in the Champions League.
Shakhtar Donetsk held on to a Europa League place despite suffering a fifth defeat in six games in Champions League Group A against Paris Saint-Germain.
David De Gea's exceptional display saved Manchester United's blushes as Jose Mourinho's men somehow escaped with a goalless draw from a match dominated by Sevilla.
Shakhtar Donetsk pulled off a second-half comeback to beat Roma 2-1 in their Champions League round-of-16 first leg in Ukraine on Wednesday night.
Bayern Munich look assured of a Champions League quarterfinal spot for a seventh straight season after thrashing 10-man Besiktas 5-0 in Germany.
Lionel Messi broke his goal duck against Chelsea to deny Antonio Conte's side a crucial lead over Barcelona in their Champions League showdown.
Sadio Mane scored a hat trick and Mohamed Salah continued his phenomenal run with a 30th goal of the season as Liverpool won 5-0 at Porto to virtually assure themselves a Champions League quarterfinal place.
Cristiano Ronaldo scored twice and Marcelo got another as Real Madrid came from a goal down to take a 3-1 lead over Paris Saint-Germain in the first leg of their Champions League clash at the Bernabeu.
Ilkay Gundogan scored twice as Manchester City put one foot in the Champions League quarterfinals with an emphatic 4-0 win over Basel.
Christian Eriksen completed a remarkable Tottenham comeback as they rallied from two down to draw with Juventus in the Champions League last 16.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.