Arda Turan scored a second-half hat-trick as Barcelona took out their domestic frustrations on Borussia Monchengladbach with a 4-0 mauling at the Nou Camp.
Paris Saint-Germain missed out on the chance to top Champions League Group A as they were held to a 2-2 draw by Ludogorets.
Lucas Perez scored a hat trick as Arsenal beat Basel 4-1 in the Champions League to top Group A ahead of Paris Saint-Germain.
Dynamo Kiev crashed out of the Champions League on a high after crushing nine-man Besiktas 6-0 at the Olympic Stadium.
Rostov went toe to toe with Bayern Munich and emerged with a shock 3-2 victory thanks to Christian Noboa's decisive free-kick.
Kevin Gameiro and Antoine Griezmann scored the goals as Atletico Madrid locked down top spot in Champions League Group D with victory over PSV Eindhoven.
Manchester City secured their place in the last 16 of the Champions League as they came from behind to claim a 1-1 draw at Borussia Monchengladbach.
Celtic were knocked out of Europe as a Lionel Messi double gave Barcelona a 2-0 Champions League win at Parkhead.
Napoli failed to open up a lead at the top of Champions League Group B as Dynamo Kiev held them to a goalless draw at the Stadio San Paolo.
Besiktas produced a stunning comeback to keep their Champions League hopes alive with a 3-3 home draw against Benfica.
Ludogorets' and Basel's battle to get out of the Champions League basement and into the Europa League will go to the sixth matchday after the teams could not be separated in Bulgaria.
Arsenal passed up the opportunity to assure themselves of qualifying for the knockout stages of the Champions League as group winners after being held to an entertaining draw at home to Paris Saint-Germain.
Hugo Lloris' penalty heroics could not rescue Tottenham's Champions League campaign as Mauricio Pochettino's men slipped to a 2-1 defeat against Monaco.
Borussia Dortmund and Legia Warsaw created Champions League history as the German side maintained their 100 percent record with a stunning 8-4 victory at a rain-soaked Signal Iduna Park.
Substitute Karim Benzema headed a late winner as holders Real Madrid secured their place in the knockout stages of the Champions League with a 2-1 victory over 10-man Sporting Lisbon at Estadio Jose Alvalade.
Late goals from Leonardo Bonucci and Mario Mandzukic saw Juventus seal their place in the Champions League knockout stages with a 3-1 win over 10-man Sevilla at the Ramon Sanchez Pizjuan.
Leicester booked their place in the knockout stages of the Champions League after surviving a second-half rally to beat Club Brugge 2-1.
Copenhagen held on despite a dominant second-half showing from Porto to record a goalless draw in their Champions League Group G clash at Telia Parken.
Lyon kept alive their hopes of reaching the Champions League knockout stages after easing to a 1-0 win over eliminated Dinamo Zagreb in Croatia.
Bayer Leverkusen are on the verge of qualifying for the Champions League knockout stages after a 1-1 draw away to CSKA Moscow on Tuesday.
Juventus will have to wait to book their place in the last 16 of the Champions League after a late Lyon goal denied them victory in Turin.
Borussia Dortmund booked their place in the knockout stages of the Champions League, despite suspending star striker Pierre-Emerick Aubameyang ahead of the 1-0 Group F win over Sporting Lisbon.
Tottenham's Wembley curse struck again as Mauricio Pochettino's men slipped to a 1-0 defeat against Bayer Leverkusen in the Champions League.
Sevilla thrashed 10-man Dinamo Zagreb 4-0 to go top of Group H and put one foot in the round of 16.
Porto moved up to second in Champions League Group G with a 1-0 home victory over Club Brugge.
Leicester missed the chance to seal qualification to the knockout stages of the Champions League after a forgettable 0-0 draw in Copenhagen.
Gareth Bale scored Real Madrid's fastest-ever goal in Champions League play but Los Blancos dropped points in an entertaining 3-3 group stage draw with Legia Warsaw behind closed doors at the Pepsi Arena on Wednesday.
Radamel Falcao scored his first Champions League goals for Monaco as they comfortably defeated CSKA Moscow 3-0 at the Stade Louis II.
Manchester City produced an outstanding second-half performance to sweep past Barcelona 3-1 at the Etihad Stadium.
A late Mesut Ozil strike saw Arsenal come from two goals down to beat Ludogorets and book a place in the round of 16 of the Champions League.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.