PSV Eindhoven secured their place in the knockout stages of the Champions League with a late 2-1 win against Group B's bottom club CSKA Moscow.
Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid hammered Malmo 8-0 to equal the highest ever victory in the Champions League.
Shakhtar Donetsk held on to a Europa League place despite suffering a fifth defeat in six games in Champions League Group A against Paris Saint-Germain.
Atletico Madrid clinched first place in Champions League Group C after winning their top-of-the-table encounter with Benfica 2-1 at the Estadio da Luz.
Galatasaray secured themselves a Europa League spot with a 1-1 Champions League Group C draw against Astana.
Mario Mandzukic scored the only goal as Juventus leapfrogged Manchester City in Champions League Group D with a 1-0 win in Turin.
Manchester United were held to a goalless draw by PSV Eindhoven at Old Trafford on Wednesday night, meaning their Champions League hopes will depend on their final group game away at Wolfsburg.
Zlatan Ibrahimovic marked his return to his hometown club by helping PSG to a 5-0 Champions League victory over Malmo at the Swedbank Stadion.
Under-fire Rafael Benitez survived a late scare on a night when Real Madrid won their Champions League group, conceding three late goals against Shakhtar Donetsk.
Wolfsburg are on the brink of qualifying for the Champions League knock-out stages after winning 2-0 at CSKA Moscow.
Atletico Madrid made sure of their place in the Champions League knock-out stages with a comfortable 2-0 win against Galatasaray at the Vicente Calderon Stadium.
Sevilla's hopes of reaching the Champions League knockout stages ended in Germany with a 4-2 defeat to Borussia Monchengladbach.
Raul Jimenez scored twice as Benfica fought back from two goals down to draw 2-2 with FC Astana in their Champions League Group C fixture and move to the brink of reaching the tournament's last 16.
Bayern Munich booked their place in the Champions League group stage with an emphatic 4-0 victory over Olympiakos.
Lionel Messi, Luis Suarez and Neymar tore Roma to shreds as Barcelona heralded their Champions League glory march with a 6-1 thumping at the Camp Nou.
Arsenal kept their Champions League hopes alive with a routine victory over Dinamo Zagreb.
Chelsea's Champions League fate will go to the final group game after an unconvincing 4-0 win over 10-man Maccabi Tel Aviv earned successive victories for the first time in two months.
Lyon are out of the Champions League after they lost their crunch Group H clash with Gent 2-1 as the Stade de Gerland hosted its final European encounter.
Porto crashed to their first defeat of the season as Group G rivals Dynamo Kiev kept their Champions League hopes alive with goals from Andriy Yarmolenko and Derlis Gonzalez at the Estadio do Dragao.
Zenit St Petersburg maintained their 100 percent record in Group H of the Champions League and guaranteed themselves top spot with a 2-0 win against Valencia.
Admir Mehmedi struck a second-half equaliser against Champions League Group E rivals BATE Borisov in Belarus to keep Bayer Leverkusen's hopes of securing a place in the knockout stages alive.
Arsenal's Champions League hopes are hanging by a thread after they were blown away by Bayern Munich on Wednesday night.
Jose Mourinho was granted a reprieve as Willian's free-kick earned a 2-1 Champions League Group G victory over Dynamo Kiev at Stamford Bridge.
Miralem Pjanic's late penalty allowed Roma to edge a resilient Bayer Leverkusen 3-2 on Wednesday and keep their hopes of qualifying for the knockout stages of the Champions League alive.
Neymar struck twice as Barcelona moved ever closer towards a place in the knockout stages of the Champions League with a 3-0 win over Group E rivals BATE Borisov.
Two second-half strikes from substitute Felipe Pardo inspired Olympiakos to a 2-1 victory over 10-man Dinamo Zagreb, sending the hosts six points clear of third-placed Arsenal in Champions League Group F.
Porto moved closer to booking their place in the last 16 of the UEFA Champions League with a 3-1 win over Maccabi Tel Aviv in Israel.
Artem Dzyuba scored twice as Zenit St. Petersburg sealed their place in the Champions League knockout stages with a 2-0 win over Lyon in France.
Sven Kums' second-half penalty was enough for Gent to down Valencia in Belgium on Wednesday night and earn the hosts an historic first win in the Champions League.
Real Madrid beat Paris Saint-Germain 1-0 in the teams' Group A Champions League match Tuesday to secure a place in the Champions League knockout round for the 19th straight season.
Lorenzo Insigne's late winner gave Napoli a deserved 1-0 Champions League victory over Liverpool on Wednesday that saw the Italians move to the top of Group C.
Mauro Icardi took advantage of an error from PSV Eindhoven goalkeeper Jeroen Zoet to gift Inter Milan a 2-1 victory in their Champions League Group B clash on Wednesday.
Borussia Dortmund's blistering start to the season under manager Lucien Favre gathered momentum as the Bundesliga leaders consigned ailing Monaco to a 3-0 defeat in the Champions League on Wednesday.
Antoine Griezmann had a goal in each half -- including the 8,000th Champions League goal -- and Koke also scored in added time to lead Atletico Madrid to a 3-1 win over Club Brugge on Wednesday.
A second-half header by Moussa Marega gave Porto a 1-0 Champions League win over Galatasaray at home on Wednesday.
Lionel Messi scored twice and powered Barcelona to a 4-2 win against Tottenham in Champions League Group B at Wembley Stadium on Wednesday night.
United States international Weston McKennie's late header gave Schalke a 1-0 win over Lokomotiv Moscow in the Champions League on Wednesday as they continued to recover from a poor start to the season.
Neymar scored his second Champions League hat trick as Paris Saint-Germain rolled to a 6-1 victory over Red Star Belgrade in a Champions League group-stage game at the Parc des Princes on Wednesday.
Roma's Edin Dzeko was again the tormentor for Viktoria Plzen as he scored a hat trick in a 5-0 Champions League Group G win for the Italian side on Tuesday.
Manchester United's dismal run of form continued as they were held to a 0-0 draw by Valencia in a drab Champions League clash at Old Trafford.
Lyon produced a stirring fightback to claw back two superb goals from Shakhtar Donetsk's Junior Moraes and rescue a 2-2 draw behind closed doors in a thrilling end-to-end contest at their Groupama Stadium on Tuesday.
A depleted Real Madrid suffered a shock 1-0 Champions League defeat at CSKA Moscow on Tuesday, extending a poor run of form for the holders that has left them without a win in three games.
Benfica played the entire second half with 10 men and squandered a two-goal lead before claiming a thrilling 3-2 win away to AEK Athens in Champions League Group E action on Tuesday.
Full-back Noussair Mazraoui earned a youthful Ajax side a 1-1 draw at misfiring Bayern Munich in their Champions League Group E clash at the Allianz Arena on Tuesday.
Paulo Dybala hit a hat-trick as Juventus maintained their 100% record in the Champions League courtesy of a 3-0 win against BSC Young Boys.
David Silva nipped in to secure a late 2-1 victory for Premier League champions Manchester City at Hoffenheim.
Cristiano Ronaldo's Champions League debut for Juventus lasted only 29 minutes as he was red-carded but the Italians began their Group H campaign impressively with a 2-0 victory at Valencia on Wednesday.
Paul Pogba scored two first-half goals as Manchester United spoiled Young Boys' first appearance in the group stage of the Champions League by cruising to a comfortable 3-0 victory at the Stade de Suisse on Wednesday.
Manchester City looked far from potential Champions League winners as they fell to a surprise 2-1 loss at home to Olympique Lyonnais on Wednesday with a flat performance that leaves them with plenty of work to do to progress from Group F.
CSKA Moscow salvaged a 2-2 draw with Viktoria Plzen in the Champions League on Wednesday after a penalty deep in stoppage time.
Bayern Munich midfielder Renato Sanches had a goal and an assist in his return to Benfica in a 2-0 victory on Wednesday.
Real Madrid rode goals from Isco and Gareth Bale to a 3-0 win against Roma in their Champions League Group G opener at the Camp Nou on Wednesday.
The youngest coach in Champions League history drew his debut game Wednesday as Hoffenheim's match at Shakhtar Donetsk finished 2-2.
Nicolas Tagliafico scored two second-half goals as Ajax marked their return to the Champions League group stages with a 3-0 victory over AEK Athens on Wednesday.
A stoppage-time goal from Roberto Firmino gave Liverpool a 3-2 win over Paris Saint-Germain on a dramatic Champions League night at Anfield.
Red Star Belgrade ground out a 0-0 home draw against Napoli on the Serbian side's Champions League debut as their goalkeeper Milan Borjan made a flurry of telling saves in a pulsating Group C clash on Tuesday.
Borussia Dortmund's United States forward Christian Pulisic came off the bench to grab a late goal for a 1-0 Champions League Group A victory over Club Brugge on Tuesday.
Atletico Madrid battled their way back from a goal down to pull off a confidence-boosting 2-1 win at AS Monaco in Champions League Group A on Tuesday, with a defiant response to their troubling start to the domestic season.
Inter Milan scored two late goals as they came from 1-0 down to beat Tottenham Hotspur 2-1 in a dramatic Champions League clash at the San Siro.
Lionel Messi scored a record-setting hat trick as Barcelona opened their Champions League campaign in Group B with an impressive 4-0 win against PSV Eindhoven at the Camp Nou.