Gary Neville watched his Valencia team slide into the Europa League after his Mestalla debut saw Lyon claim a 2-0 Champions League victory.
Denys Garmash's goal was enough to give Dynamo Kiev a 1-0 win over Maccabi Tel Aviv and send them through to the knockout stages of the Champions League.
Roma squeezed through to the Champions League last 16 after being held to a 0-0 draw at home by BATE Borisov in their final Group E game.
CSKA Moscow were unable to pull off a shock win over PSV Eindhoven, and United now face the prospect of playing Europa League football in the new year.
Sevilla will try to defend their Europa League crown after a 1-0 home win over Juventus secured them third place in Champions League Group D.
Raheem Sterling celebrated his 21st birthday with a quickfire double to send Manchester City through to the Champions League last 16 as group winners.
PSV Eindhoven secured their place in the knockout stages of the Champions League with a late 2-1 win against Group B's bottom club CSKA Moscow.
Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid hammered Malmo 8-0 to equal the highest ever victory in the Champions League.
Shakhtar Donetsk held on to a Europa League place despite suffering a fifth defeat in six games in Champions League Group A against Paris Saint-Germain.
Atletico Madrid clinched first place in Champions League Group C after winning their top-of-the-table encounter with Benfica 2-1 at the Estadio da Luz.
Galatasaray secured themselves a Europa League spot with a 1-1 Champions League Group C draw against Astana.
Mario Mandzukic scored the only goal as Juventus leapfrogged Manchester City in Champions League Group D with a 1-0 win in Turin.
Manchester United were held to a goalless draw by PSV Eindhoven at Old Trafford on Wednesday night, meaning their Champions League hopes will depend on their final group game away at Wolfsburg.
Zlatan Ibrahimovic marked his return to his hometown club by helping PSG to a 5-0 Champions League victory over Malmo at the Swedbank Stadion.
Under-fire Rafael Benitez survived a late scare on a night when Real Madrid won their Champions League group, conceding three late goals against Shakhtar Donetsk.
Wolfsburg are on the brink of qualifying for the Champions League knock-out stages after winning 2-0 at CSKA Moscow.
Atletico Madrid made sure of their place in the Champions League knock-out stages with a comfortable 2-0 win against Galatasaray at the Vicente Calderon Stadium.
Sevilla's hopes of reaching the Champions League knockout stages ended in Germany with a 4-2 defeat to Borussia Monchengladbach.
Raul Jimenez scored twice as Benfica fought back from two goals down to draw 2-2 with FC Astana in their Champions League Group C fixture and move to the brink of reaching the tournament's last 16.
Bayern Munich booked their place in the Champions League group stage with an emphatic 4-0 victory over Olympiakos.
Lionel Messi, Luis Suarez and Neymar tore Roma to shreds as Barcelona heralded their Champions League glory march with a 6-1 thumping at the Camp Nou.
Arsenal kept their Champions League hopes alive with a routine victory over Dinamo Zagreb.
Chelsea's Champions League fate will go to the final group game after an unconvincing 4-0 win over 10-man Maccabi Tel Aviv earned successive victories for the first time in two months.
Lyon are out of the Champions League after they lost their crunch Group H clash with Gent 2-1 as the Stade de Gerland hosted its final European encounter.
Porto crashed to their first defeat of the season as Group G rivals Dynamo Kiev kept their Champions League hopes alive with goals from Andriy Yarmolenko and Derlis Gonzalez at the Estadio do Dragao.
Zenit St Petersburg maintained their 100 percent record in Group H of the Champions League and guaranteed themselves top spot with a 2-0 win against Valencia.
Admir Mehmedi struck a second-half equaliser against Champions League Group E rivals BATE Borisov in Belarus to keep Bayer Leverkusen's hopes of securing a place in the knockout stages alive.
Arsenal's Champions League hopes are hanging by a thread after they were blown away by Bayern Munich on Wednesday night.
Jose Mourinho was granted a reprieve as Willian's free-kick earned a 2-1 Champions League Group G victory over Dynamo Kiev at Stamford Bridge.
Miralem Pjanic's late penalty allowed Roma to edge a resilient Bayer Leverkusen 3-2 on Wednesday and keep their hopes of qualifying for the knockout stages of the Champions League alive.
Liverpool face Manchester City in an all-English Champions League quarterfinal after the draw in Switzerland on Friday.
Two goals from Lionel Messi -- one the fastest of his career and the other his 100th in the Champions League -- helped Barcelona beat Chelsea 3-0 at the Camp Nou and advance to the quarterfinals 4-1 on aggregate.
Bayern Munich coasted into the quarterfinals of the Champions League with a 3-1 win over Besiktas in Istanbul to complete an 8-1 aggregate win.
A second-half strike from Edin Dzeko sent Roma into the quarterfinals of the Champions League with a 1-0 home victory against 10-man Shakhtar Donetsk.
Sevilla are through to the Champions League quarterfinals after beating Manchester United 2-1 in their second leg at Old Trafford on Tuesday night.
Manchester City slipped to their first home defeat since December 2016 as Basel won the second leg of their Champions League last-16 tie 2-1.
Two goals in under three second-half minutes saw Juventus come back from 1-0 down to knock Tottenham Hotspur out of the Champions League, with a 2-1 win at Wembley putting them through to the quarterfinals 4-3 on aggregate.
Liverpool eased into the quarterfinals of the Champions League for the first time in nine years with no great alarm in a lifeless goalless draw at home to Porto.
Holders Real Madrid eased into the Champions League quarterfinals with a 2-1 win at 10-man Paris Saint-Germain.
David De Gea's exceptional display saved Manchester United's blushes as Jose Mourinho's men somehow escaped with a goalless draw from a match dominated by Sevilla.
Shakhtar Donetsk pulled off a second-half comeback to beat Roma 2-1 in their Champions League round-of-16 first leg in Ukraine on Wednesday night.
Bayern Munich look assured of a Champions League quarterfinal spot for a seventh straight season after thrashing 10-man Besiktas 5-0 in Germany.
Lionel Messi broke his goal duck against Chelsea to deny Antonio Conte's side a crucial lead over Barcelona in their Champions League showdown.
Sadio Mane scored a hat trick and Mohamed Salah continued his phenomenal run with a 30th goal of the season as Liverpool won 5-0 at Porto to virtually assure themselves a Champions League quarterfinal place.
Cristiano Ronaldo scored twice and Marcelo got another as Real Madrid came from a goal down to take a 3-1 lead over Paris Saint-Germain in the first leg of their Champions League clash at the Bernabeu.
Ilkay Gundogan scored twice as Manchester City put one foot in the Champions League quarterfinals with an emphatic 4-0 win over Basel.
Christian Eriksen completed a remarkable Tottenham comeback as they rallied from two down to draw with Juventus in the Champions League last 16.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.