Paris Saint-Germain missed out on the chance to top Champions League Group A as they were held to a 2-2 draw by Ludogorets.
Lucas Perez scored a hat trick as Arsenal beat Basel 4-1 in the Champions League to top Group A ahead of Paris Saint-Germain.
Dynamo Kiev crashed out of the Champions League on a high after crushing nine-man Besiktas 6-0 at the Olympic Stadium.
Rostov went toe to toe with Bayern Munich and emerged with a shock 3-2 victory thanks to Christian Noboa's decisive free-kick.
Kevin Gameiro and Antoine Griezmann scored the goals as Atletico Madrid locked down top spot in Champions League Group D with victory over PSV Eindhoven.
Manchester City secured their place in the last 16 of the Champions League as they came from behind to claim a 1-1 draw at Borussia Monchengladbach.
Celtic were knocked out of Europe as a Lionel Messi double gave Barcelona a 2-0 Champions League win at Parkhead.
Napoli failed to open up a lead at the top of Champions League Group B as Dynamo Kiev held them to a goalless draw at the Stadio San Paolo.
Besiktas produced a stunning comeback to keep their Champions League hopes alive with a 3-3 home draw against Benfica.
Ludogorets' and Basel's battle to get out of the Champions League basement and into the Europa League will go to the sixth matchday after the teams could not be separated in Bulgaria.
Arsenal passed up the opportunity to assure themselves of qualifying for the knockout stages of the Champions League as group winners after being held to an entertaining draw at home to Paris Saint-Germain.
Hugo Lloris' penalty heroics could not rescue Tottenham's Champions League campaign as Mauricio Pochettino's men slipped to a 2-1 defeat against Monaco.
Borussia Dortmund and Legia Warsaw created Champions League history as the German side maintained their 100 percent record with a stunning 8-4 victory at a rain-soaked Signal Iduna Park.
Substitute Karim Benzema headed a late winner as holders Real Madrid secured their place in the knockout stages of the Champions League with a 2-1 victory over 10-man Sporting Lisbon at Estadio Jose Alvalade.
Late goals from Leonardo Bonucci and Mario Mandzukic saw Juventus seal their place in the Champions League knockout stages with a 3-1 win over 10-man Sevilla at the Ramon Sanchez Pizjuan.
Leicester booked their place in the knockout stages of the Champions League after surviving a second-half rally to beat Club Brugge 2-1.
Copenhagen held on despite a dominant second-half showing from Porto to record a goalless draw in their Champions League Group G clash at Telia Parken.
Lyon kept alive their hopes of reaching the Champions League knockout stages after easing to a 1-0 win over eliminated Dinamo Zagreb in Croatia.
Bayer Leverkusen are on the verge of qualifying for the Champions League knockout stages after a 1-1 draw away to CSKA Moscow on Tuesday.
Juventus will have to wait to book their place in the last 16 of the Champions League after a late Lyon goal denied them victory in Turin.
Borussia Dortmund booked their place in the knockout stages of the Champions League, despite suspending star striker Pierre-Emerick Aubameyang ahead of the 1-0 Group F win over Sporting Lisbon.
Tottenham's Wembley curse struck again as Mauricio Pochettino's men slipped to a 1-0 defeat against Bayer Leverkusen in the Champions League.
Sevilla thrashed 10-man Dinamo Zagreb 4-0 to go top of Group H and put one foot in the round of 16.
Porto moved up to second in Champions League Group G with a 1-0 home victory over Club Brugge.
Leicester missed the chance to seal qualification to the knockout stages of the Champions League after a forgettable 0-0 draw in Copenhagen.
Gareth Bale scored Real Madrid's fastest-ever goal in Champions League play but Los Blancos dropped points in an entertaining 3-3 group stage draw with Legia Warsaw behind closed doors at the Pepsi Arena on Wednesday.
Radamel Falcao scored his first Champions League goals for Monaco as they comfortably defeated CSKA Moscow 3-0 at the Stade Louis II.
Manchester City produced an outstanding second-half performance to sweep past Barcelona 3-1 at the Etihad Stadium.
A late Mesut Ozil strike saw Arsenal come from two goals down to beat Ludogorets and book a place in the round of 16 of the Champions League.
Thomas Meunier volleyed home a stunning late winner as Paris Saint-Germain guaranteed their place in the last 16 of the Champions League with a dramatic 2-1 win over Basel.
Lorenzo Insigne's late winner gave Napoli a deserved 1-0 Champions League victory over Liverpool on Wednesday that saw the Italians move to the top of Group C.
Mauro Icardi took advantage of an error from PSV Eindhoven goalkeeper Jeroen Zoet to gift Inter Milan a 2-1 victory in their Champions League Group B clash on Wednesday.
Borussia Dortmund's blistering start to the season under manager Lucien Favre gathered momentum as the Bundesliga leaders consigned ailing Monaco to a 3-0 defeat in the Champions League on Wednesday.
Antoine Griezmann had a goal in each half -- including the 8,000th Champions League goal -- and Koke also scored in added time to lead Atletico Madrid to a 3-1 win over Club Brugge on Wednesday.
A second-half header by Moussa Marega gave Porto a 1-0 Champions League win over Galatasaray at home on Wednesday.
Lionel Messi scored twice and powered Barcelona to a 4-2 win against Tottenham in Champions League Group B at Wembley Stadium on Wednesday night.
United States international Weston McKennie's late header gave Schalke a 1-0 win over Lokomotiv Moscow in the Champions League on Wednesday as they continued to recover from a poor start to the season.
Neymar scored his second Champions League hat trick as Paris Saint-Germain rolled to a 6-1 victory over Red Star Belgrade in a Champions League group-stage game at the Parc des Princes on Wednesday.
Roma's Edin Dzeko was again the tormentor for Viktoria Plzen as he scored a hat trick in a 5-0 Champions League Group G win for the Italian side on Tuesday.
Manchester United's dismal run of form continued as they were held to a 0-0 draw by Valencia in a drab Champions League clash at Old Trafford.
Lyon produced a stirring fightback to claw back two superb goals from Shakhtar Donetsk's Junior Moraes and rescue a 2-2 draw behind closed doors in a thrilling end-to-end contest at their Groupama Stadium on Tuesday.
A depleted Real Madrid suffered a shock 1-0 Champions League defeat at CSKA Moscow on Tuesday, extending a poor run of form for the holders that has left them without a win in three games.
Benfica played the entire second half with 10 men and squandered a two-goal lead before claiming a thrilling 3-2 win away to AEK Athens in Champions League Group E action on Tuesday.
Full-back Noussair Mazraoui earned a youthful Ajax side a 1-1 draw at misfiring Bayern Munich in their Champions League Group E clash at the Allianz Arena on Tuesday.
Paulo Dybala hit a hat-trick as Juventus maintained their 100% record in the Champions League courtesy of a 3-0 win against BSC Young Boys.
David Silva nipped in to secure a late 2-1 victory for Premier League champions Manchester City at Hoffenheim.
Cristiano Ronaldo's Champions League debut for Juventus lasted only 29 minutes as he was red-carded but the Italians began their Group H campaign impressively with a 2-0 victory at Valencia on Wednesday.
Paul Pogba scored two first-half goals as Manchester United spoiled Young Boys' first appearance in the group stage of the Champions League by cruising to a comfortable 3-0 victory at the Stade de Suisse on Wednesday.
Manchester City looked far from potential Champions League winners as they fell to a surprise 2-1 loss at home to Olympique Lyonnais on Wednesday with a flat performance that leaves them with plenty of work to do to progress from Group F.
CSKA Moscow salvaged a 2-2 draw with Viktoria Plzen in the Champions League on Wednesday after a penalty deep in stoppage time.
Bayern Munich midfielder Renato Sanches had a goal and an assist in his return to Benfica in a 2-0 victory on Wednesday.
Real Madrid rode goals from Isco and Gareth Bale to a 3-0 win against Roma in their Champions League Group G opener at the Camp Nou on Wednesday.
The youngest coach in Champions League history drew his debut game Wednesday as Hoffenheim's match at Shakhtar Donetsk finished 2-2.
Nicolas Tagliafico scored two second-half goals as Ajax marked their return to the Champions League group stages with a 3-0 victory over AEK Athens on Wednesday.
A stoppage-time goal from Roberto Firmino gave Liverpool a 3-2 win over Paris Saint-Germain on a dramatic Champions League night at Anfield.
Red Star Belgrade ground out a 0-0 home draw against Napoli on the Serbian side's Champions League debut as their goalkeeper Milan Borjan made a flurry of telling saves in a pulsating Group C clash on Tuesday.
Borussia Dortmund's United States forward Christian Pulisic came off the bench to grab a late goal for a 1-0 Champions League Group A victory over Club Brugge on Tuesday.
Atletico Madrid battled their way back from a goal down to pull off a confidence-boosting 2-1 win at AS Monaco in Champions League Group A on Tuesday, with a defiant response to their troubling start to the domestic season.
Inter Milan scored two late goals as they came from 1-0 down to beat Tottenham Hotspur 2-1 in a dramatic Champions League clash at the San Siro.
Lionel Messi scored a record-setting hat trick as Barcelona opened their Champions League campaign in Group B with an impressive 4-0 win against PSV Eindhoven at the Camp Nou.