Hugo Lloris' penalty heroics could not rescue Tottenham's Champions League campaign as Mauricio Pochettino's men slipped to a 2-1 defeat against Monaco.
Borussia Dortmund and Legia Warsaw created Champions League history as the German side maintained their 100 percent record with a stunning 8-4 victory at a rain-soaked Signal Iduna Park.
Substitute Karim Benzema headed a late winner as holders Real Madrid secured their place in the knockout stages of the Champions League with a 2-1 victory over 10-man Sporting Lisbon at Estadio Jose Alvalade.
Late goals from Leonardo Bonucci and Mario Mandzukic saw Juventus seal their place in the Champions League knockout stages with a 3-1 win over 10-man Sevilla at the Ramon Sanchez Pizjuan.
Leicester booked their place in the knockout stages of the Champions League after surviving a second-half rally to beat Club Brugge 2-1.
Copenhagen held on despite a dominant second-half showing from Porto to record a goalless draw in their Champions League Group G clash at Telia Parken.
Lyon kept alive their hopes of reaching the Champions League knockout stages after easing to a 1-0 win over eliminated Dinamo Zagreb in Croatia.
Bayer Leverkusen are on the verge of qualifying for the Champions League knockout stages after a 1-1 draw away to CSKA Moscow on Tuesday.
Juventus will have to wait to book their place in the last 16 of the Champions League after a late Lyon goal denied them victory in Turin.
Borussia Dortmund booked their place in the knockout stages of the Champions League, despite suspending star striker Pierre-Emerick Aubameyang ahead of the 1-0 Group F win over Sporting Lisbon.
Tottenham's Wembley curse struck again as Mauricio Pochettino's men slipped to a 1-0 defeat against Bayer Leverkusen in the Champions League.
Sevilla thrashed 10-man Dinamo Zagreb 4-0 to go top of Group H and put one foot in the round of 16.
Porto moved up to second in Champions League Group G with a 1-0 home victory over Club Brugge.
Leicester missed the chance to seal qualification to the knockout stages of the Champions League after a forgettable 0-0 draw in Copenhagen.
Gareth Bale scored Real Madrid's fastest-ever goal in Champions League play but Los Blancos dropped points in an entertaining 3-3 group stage draw with Legia Warsaw behind closed doors at the Pepsi Arena on Wednesday.
Radamel Falcao scored his first Champions League goals for Monaco as they comfortably defeated CSKA Moscow 3-0 at the Stade Louis II.
Manchester City produced an outstanding second-half performance to sweep past Barcelona 3-1 at the Etihad Stadium.
A late Mesut Ozil strike saw Arsenal come from two goals down to beat Ludogorets and book a place in the round of 16 of the Champions League.
Thomas Meunier volleyed home a stunning late winner as Paris Saint-Germain guaranteed their place in the last 16 of the Champions League with a dramatic 2-1 win over Basel.
Robert Lewandowski scored twice as Bayern Munich came from behind to beat PSV Eindhoven 2-1 at Philips Stadion and secure their place in the knockout stages of the Champions League.
Antoine Griezmann grabbed a stoppage-time winner as Atletico Madrid maintained their 100 per cent record in Champions League Group D with a 2-1 win over Rostov at the Vicente Calderon Stadium.
Moussa Dembele's second-half penalty gave Celtic a 1-1 draw at Borussia Monchengladbach on Tuesday to keep their Champions League hopes alive.
Eduardo Salvio's cool first-half penalty was enough to earn Benfica a valuable 1-0 win in their Champions League Group B clash with Dynamo Kiev at the Estadio da Luz.
A brilliant late goal from Napoli captain Marek Hamsik secured a 1-1 draw at Besiktas to keep the Italians a point ahead of their opponents in Champions League Group B.
Lionel Messi and Cristiano Ronaldo are set to resume their annual battle for the Ballon d'Or after both were named in the list of 30 nominees for the 2016 award on Monday.
Lionel Messi scored a hat trick in a sensational display as Barcelona beat Manchester City 4-0 at the Camp Nou on Wednesday.
Bayern Munich won for the first time in four games as Joshua Kimmich's scoring run continued in a 4-1 success over PSV Eindhoven.
Angel Di Maria scored his first goal of the season to put Paris St Germain on course for a 3-0 Champions League win over Basel.
A Mesut Ozil hat trick spearheaded Arsenal's 6-0 Champions League demolition of Ludogorets at the Emirates Stadium.
Yannick Carrasco scored the only goal of the game as Atletico Madrid maintained their 100 percent record in Champions League Group D with a 1-0 win at Rostov.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.
Willian scored twice and was fouled for two penalties as Chelsea cruised into the Champions League knockout stages with a 4-0 win over 10-man Qarabag at the Olympic Stadium in Baku.
Antoine Griezmann's stunning goal kept Atletico Madrid's Champions League hopes alive as they grabbed a vital victory over Roma.
Celtic suffered another night of European anguish against Paris St Germain in a 7-1 thrashing in the Parc des Princes.
Raheem Sterling struck a late winner as Manchester City secured top spot in Champions League Group F with a 1-0 win over Feyenoord.
Cristiano Ronaldo set another Champions League record as holders Real Madrid sealed their place in the knockout stages with a comprehensive victory against Apoel Nicosia.
Lorenzo Insigne's magical strike broke Shakhtar Donetsk's defences and Napoli went on to a 3-0 win, which gives them hope of Champions League progress.
Liverpool squandered a three-goal half-time lead to throw away the chance of early Champions League qualification as Sevilla netted a 93rd-minute equaliser in Spain.
Son Heung-Min proved the scourge of Borussia Dortmund again as his late winner ensured Tottenham will go through to the Champions League round of 16 as group winners.