Bayern Munich confirmed their spot in the Champions League quarterfinals with a 5-1 win at 10-man Arsenal on Tuesday to advance 10-2 on aggregate.
Juventus struck twice in the second half to take control of their Champions League round-of-16 tie against 10-man Porto.
Jamie Vardy's first Champions League strike gave Leicester a crucial away goal in a 2-1 defeat at Sevilla, giving them a foothold in a tie in which they had trailed 2-0.
Manchester City overcame Monaco in an eight-goal thriller at the Etihad Stadium, coming from behind to run out 5-3 winners in their Champions League round-of-16 first leg.
Atletico Madrid opened their Champions League knockout stage with a 4-2 win away to Bayer Leverkusen in the round of 16 first leg on Tuesday.
Two goals in five second-half minutes helped Real Madrid come from behind to beat Napoli 3-1 in the first leg of their UEFA Champions League last-16 clash at the Bernabeu on Wednesday.
Arsenal will have to produce something special to reach a first Champions League quarterfinal since 2010 after suffering a 5-1 defeat to a rampant Bayern Munich side in the first leg of their round-of-16 tie at the Allianz Arena.
Two goals from Angel Di Maria and one apiece from Julian Draxler and Edinson Cavani gave Paris Saint-Germain an unexpected and potentially unassailable 4-0 lead against Barcelona in their Champions League round of 16 first leg tie.
Kostas Mitroglou scored the only goal of the game as Benfica took advantage of Pierre-Emerick Aubameyang's off day to grab control of their Champions League last-16 tie against Borussia Dortmund in Lisbon.
Cristiano Ronaldo scored a hat trick as Real Madrid claimed their second Club World Cup title in three years, but the Spanish giants needed extra time to see off the spirited Kashima Antlers 4-2 in Yokohama.
Arsenal have been drawn against Bayern Munich in the Champions League's round of 16, while Barcelona will take on Paris Saint-Germain.
Real Madrid's Cristiano Ronaldo won the Ballon d'Or for a fourth time on Monday night, beating Barcelona's Lionel Messi and Atletico Madrid's Antoine Griezmann to world football's top individual prize for 2016.
Sevilla qualified for the last 16 of the Champions League after holding Lyon to a goalless draw.
Legia Warsaw secured a place in the Europa League at the expense of 10-man Sporting Lisbon after a 1-0 Champions League Group F win at the Polish Army Stadium.
FC Copenhagen ended their Champions League Group G with a 2-0 victory over Club Brugge but Porto's thumping win over Leicester condemned them to the Europa League.
Bayer Leverkusen inflicted a first defeat in 10 matches on Monaco in their Champions League Group E match on Wednesday.
Woeful Leicester lost their unbeaten Champions League record as a second string side suffered a humiliating 5-0 thumping in Porto.
Tottenham's winless Wembley run is over but their Europa League campaign has just begun after Mauricio Pochettino's men sealed a 3-1 win over CSKA Moscow.
Gonzalo Higuain's stunning strike saw Juventus finish on top of Champions League Group H as they beat Dinamo Zagreb 2-0 in Turin.
Real Madrid squandered a two-goal lead and with it top spot in Group F as record-breaking Borussia Dortmund fought back to draw 2-2 late on at the Bernabeu.
Napoli secured top spot in Group B with a 2-1 victory at Benfica as both sides progressed into the knockout stages of the Champions League.
Rostov battled to a goalless draw in their final Champions League Group D fixture away at PSV Eindhoven, which was enough for the Russians to reach the Europa League.
Robert Lewandowski's first-half free kick proved enough to give Bayern Munich a 1-0 win over Atletico Madrid at the Allianz Arena and end the Spanish side's hopes of finishing their Champions League Group D campaign with six wins from six.
Patrick Roberts scored against his parent club as Celtic held Manchester City to a 1-1 draw in their final Champions League Group C game.
Arda Turan scored a second-half hat-trick as Barcelona took out their domestic frustrations on Borussia Monchengladbach with a 4-0 mauling at the Nou Camp.
Paris Saint-Germain missed out on the chance to top Champions League Group A as they were held to a 2-2 draw by Ludogorets.
Lucas Perez scored a hat trick as Arsenal beat Basel 4-1 in the Champions League to top Group A ahead of Paris Saint-Germain.
Dynamo Kiev crashed out of the Champions League on a high after crushing nine-man Besiktas 6-0 at the Olympic Stadium.
Rostov went toe to toe with Bayern Munich and emerged with a shock 3-2 victory thanks to Christian Noboa's decisive free-kick.
Kevin Gameiro and Antoine Griezmann scored the goals as Atletico Madrid locked down top spot in Champions League Group D with victory over PSV Eindhoven.
Bayern Munich look assured of a Champions League quarterfinal spot for a seventh straight season after thrashing 10-man Besiktas 5-0 in Germany.
Lionel Messi broke his goal duck against Chelsea to deny Antonio Conte's side a crucial lead over Barcelona in their Champions League showdown.
Sadio Mane scored a hat trick and Mohamed Salah continued his phenomenal run with a 30th goal of the season as Liverpool won 5-0 at Porto to virtually assure themselves a Champions League quarterfinal place.
Cristiano Ronaldo scored twice and Marcelo got another as Real Madrid came from a goal down to take a 3-1 lead over Paris Saint-Germain in the first leg of their Champions League clash at the Bernabeu.
Ilkay Gundogan scored twice as Manchester City put one foot in the Champions League quarterfinals with an emphatic 4-0 win over Basel.
Christian Eriksen completed a remarkable Tottenham comeback as they rallied from two down to draw with Juventus in the Champions League last 16.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.
Willian scored twice and was fouled for two penalties as Chelsea cruised into the Champions League knockout stages with a 4-0 win over 10-man Qarabag at the Olympic Stadium in Baku.
Antoine Griezmann's stunning goal kept Atletico Madrid's Champions League hopes alive as they grabbed a vital victory over Roma.